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ea0037gp.22.05 | Pituitary–Therapy of Cushing's disease | ECE2015

Effects of osilodrostat (LCI699) on cytochrome P450 enzymes in healthy volunteers indicates a low drug–drug interaction potential

Ting Lillian , Tripathi Anadya Prakash , Darstein Christelle , White Tracy , Sauter Nicholas

Introduction: In vitro assessments of osilodrostat (LCI699), a potent oral inhibitor of 11β-hydroxylase suggested potential drug–drug interactions (DDIs) with cytochrome P450 (CYP) enzyme metabolism. This clinical study evaluated the effect of osilodrostat on the pharmacokinetics (PK) of CYP1A2, CYP2C19, CYP2D6, and CYP3A4 probe substrates, caffeine, omeprazole, dextromethorphan, and midazolam, respectively.Methods: A single-centre, op...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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